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Category: Research

Lifesaving star: Low volume resuscitant for prehospital treatment of severe hemorrhagic shock

July 23, 2024

Extensive blood loss after injuries is life-threatening and must be counteracted as fast as possible. Relatively small volume injections of solutions of a novel star-shaped polymer could compensate for fluid loss without disrupting coagulation. [...]

Q&A: How a potential treatment for Alzheimer’s disease could also work for Type 2 diabetes

April 16, 2024

Of the 38 million Americans who have diabetes at least 90% have Type 2, according to the Centers for Disease Control and Prevention. Type 2 diabetes occurs over time and is characterized by a loss of the cells in the pancreas that make the hormone insulin, which helps the body manage sugar. [...]

Recruiting robots for materials discovery

April 11, 2024

Chemical engineers in the Pozzo Research Group are using open-source tools to build modular robots that can run multiple functions of complex experiments. This customizable framework helps alleviate the cost barrier of purchasing multiple, single-purpose commercial machines. [...]

Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells

January 30, 2024

When researchers want to study how COVID makes us sick, or what diseases such as Alzheimer’s do to the body, one approach is to look at what’s happening inside individual cells. Researchers sometimes grow the cells in a 3D scaffold called a “hydrogel.” This network of proteins or molecules mimics the environment the cells would [...]

Retooling microbes to upcycle CO2

September 13, 2022

An interdisciplinary, UW-led team of synthetic biologists will embark on a 5-year, $15 million project to engineer microbial genomes that transform CO2 into high-value chemicals. [...]

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Unlocking biotechnology with RNA

May 17, 2022

Two recent molecular engineering graduates launched a new startup, Wayfinder Biosciences, to commercialize their revolutionary platform to design RNA molecules that can be used to advance everything from sustainable biomanufacturing to targeted CRISPR therapies. [...]

Q&A: Making Earth-friendly electronics

April 21, 2022

Three UW researchers, including MolES faculty member Eleftheria Roumeli, are exploring ways to make electronics more Earth-friendly. [...]

Novel nanoparticle shows promise for treating aggressive breast cancer

March 17, 2022

Scientists at the University of Washington have recently developed a new nanoparticle-based drug delivery system that simultaneously delivers chemo- and immune- therapeutics directly to the tumor site, limiting harmful off-target side effects. In a paper published last November in Materials Today, they reported that their multifunctional nanoparticle can inhibit tumor growth and spread, also known as metastasis, in mouse models of triple negative breast cancer, an exceptionally aggressive form of breast cancer with limited treatment options. [...]

Corie L. Cobb awarded DARPA Director’s Fellowship

January 24, 2022

Corie L. Cobb, professor of mechanical engineering and the Washington Research Foundation Innovation Professor in Clean Energy, has been selected as recipient of the prestigious Defense Advanced Research Projects Agency (DARPA) Director's Fellowship Award. [...]

Northwest Nanotechnology Infrastructure announces new seed grants

January 6, 2022

To support the use of nanotechnology tools to develop innovative, new technologies, the Northwest Nanotechnology Infrastructure (NNI) is offering seed grants for work to be conducted in our fabrication or characterization facilities. These grants are designed to help users build and characterize prototypes, obtain preliminary results and conduct proof of concept studies. [...]

Six MolES faculty among world's most influential researchers

November 23, 2021

Six researchers affiliated with the Molecular Engineering & Sciences Institute are among the most influential in the world, according to the annual Highly Cited Researchers list published by the Web of Science, the world's largest publisher-neutral citation index. [...]

UW BIOFAB: A force for reproducible science

November 17, 2021

The UW's Biofabrication Center, a unique facility dedicated to enabling the rapid design, construction and testing of genetically reprogrammed organisms, is partnering with Agilent Technologies in pursuit of automated, reproducible research. [...]

Tiny structures, big impact

October 12, 2021

Miqin Zhang is working to improve cancer treatment with nanoparticles made from the same material found in crustacean shells. [...]

NSF to fund revolutionary center for optoelectronic, quantum technologies

September 9, 2021

The National Science Foundation has announced it will fund a new endeavor to bring atomic-level precision to the devices and technologies that underpin much of modern life, and will transform fields like information technology in the decades to come. The five-year, $25 million Science and Technology Center grant will found the Center for Integration of Modern Optoelectronic Materials on Demand "” or IMOD "” a collaboration of scientists and engineers at 11 universities led by the University of Washington. [...]

University of Washington and Microsoft researchers develop "nanopore-tal" enabling cells to talk to computers

August 12, 2021

The research team, which includes MolE graduate student Nicolas Cardozo, introduce a new class of reporter proteins that can be directly read by a commercially available nanopore sensing device. The new system "• dubbed "Nanopore-addressable protein Tags Engineered as Reporters," also known as NanoporeTERs or NTERs for short "• can perform multiplexed detection of protein expression levels from bacterial and human cell cultures far beyond the capacity of existing techniques. [...]

UW synthetic biologist James Carothers wins ARPA-E award to develop new CO2 bioconversion process

July 13, 2021

The funding will be used to develop scalable, cell-free platforms that enable the capture and conversion of carbon dioxide into industrial chemicals, providing manufacturers with a cheaper, more efficient and sustainable means of chemical production. [...]

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Alzheimer's research gets a boost

April 6, 2021

Bioengineering startup AltPep advances technology for the early detection and treatment of Alzheimer's and other amyloid diseases. [...]

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Role of solvent molecules in light-driven electron transfer revealed

March 12, 2021

In a study published in Nature Chemistry, a research team led by MolES faculty member Munira Khalil, professor and chair of chemistry at the UW, has captured the rapid motions of solvent molecules that impact light-driven electron transfer in a molecular complex for the first time. This information could help researchers learn how to control energy flow in molecules, potentially leading to more efficient clean energy sources. [...]

Researchers use lasers and molecular tethers to create perfectly patterned platforms for tissue engineering

January 18, 2021

MolES faculty member Cole DeForest and colleagues have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies. [...]

A culture of collaboration

November 17, 2020

MolES faculty members Barry Lutz and Paul Yager pivoted their diagnostics research to support the need for COVID-19 testing. [...]