Dr. Sean Mooney is the Chief Research Information Officer (CRIO) of UW Medicine, the Director of Informatics for the Institute of Translational Health Sciences, an Associate Director of the National Alzheimers Coordinating Center (NACC), the Interim Director of the UW Institute for Medical Data Science, and a Professor in the Department of Biomedical Informatics and Medical Education at the University of Washington. As CRIO, he leads the growing Research Information Technology team that contributes to a number of national research networks the National Kidney Precision Medicine Project, the National Alzheimer’s Coordinating Center, the UW Clear Center and others. Some notable efforts include leading the team that developed the open source Leaf application for clinical data querying and extraction, managed a REDCap instance with >25k projects and >15k active users, managing the FH, UW and Seattle Cancer Care Alliance joint CTMS application, and enhancing the UW Medicine EDW with advanced analytics including NLP. Currently he is focusing on developing an Epic EHR Research team for supporting research in the EHR at UW Medicine and leading the newly founded UW Institute for Medical Data Science. His research interests focus on data science applications in biomedicine, particularly in understanding the underlying molecular causes of inherited genetic diseases and cancer.